RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
mir-34a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
Masson's trichrome staining; qRT-PCR; etc.
Target
Sirt1; E2f3; Cyclin E2
Pathway
NA
PubMed ID
Title
MiR-34a promotes fibrosis in aged lungs by inducing alveolar epithelial dysfunctions
Year
2016
Function
"MiR-34a was upregulated in lung epithelial cells of aged mice, and was further increased in epithelial cells of the fibrotic lungs of these old animals. MiR-34a induced dysfunctions in alveolar epithelial cells (AECs), as evidenced by increased cellular senescence and apoptosis and mitochondrial aberrations. More importantly, these abnormalities were attenuated in AECs of the fibrotic lungs of aged miR-34a-/- mice. MiR-34a targeted Sirt1, E2F3 and cyclin E2 in lung epithelial cells, and the repression of these targets was relieved in miR-34a-deficient AECs."